Synergistic Effect of Incorporation of BG 45S5 and Silver Nanoparticles on β-TCP Scaffolds: Structural Characterization and Evaluation of Antimicrobial Activity and Biocompatibility

Bacterial infections after implant surgical procedures are a complication observed in many surgeries to treat bone injuries or diseases. Bacteria can attach the surface of producing biofilms, and if treatment with antibiotics does not work, further surgery is necessary remove infected implant. Among biomaterials for implants, bioceramics based on calcium phosphates (CaPs) such as β-TCP stand out, due their chemical similarity high bioresorbability. has characteristic easily accommodating its crystalline structure reasonable amounts doping elements, monovalent trivalent ions, which makes it an efficient transporter drugs, molecules, therapeutic ions The objective this work was incorporation bioactive glass (BG 45S5) via sol-gel silver nanoparticles (Ag-NPs) scaffolds, aiming confer antimicrobial activity without prejudice biocompatibility. XRD FT-IR analysis indicated structural changes BG 45S5 Ag-NPs these compounds induced partial transformation phase into α-TCP formation sodium-calcium silicates silicates. spectra showed bands incorporation, addition predominant β-TCP. Biocompatibility improved, significant increase cell viability. After Ag-NPs, viability maintained at acceptable level, no cytotoxic behavior observed, scaffolds antibacterial antifungal activity. results indicate that incorporated synergistic behavior, conferring compromising biocompatibility, showing great potential applicability tissue engineering.